Multidrug Resistance (MDR) in Lung Cancer: Finding the Holy Grail of MDR Reversal
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چکیده
منابع مشابه
Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells.
P-glycoprotein (Pgp), a membrane transporter encoded by the MDR1 gene in human cells, mediates drug efflux from cells, and it plays a major role in causing multidrug resistance (MDR). Confocal microscopy was used to study in vitro and in vivo drug accumulation, net uptake and efflux, and MDR modulation by P-glycoprotein inhibitors in MDR1-transduced human MDA-MB-435mdr (MDR) cancer cells. The M...
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ژورنال
عنوان ژورنال: Journal of Cancer Science & Therapy
سال: 2018
ISSN: 1948-5956
DOI: 10.4172/1948-5956.s11-e001